Under PHS Policy Principles 4-9, which principle requires that procedures with potential pain or distress be performed with appropriate sedation, analgesia, or anesthesia?

Under PHS Policy Principles 4-9, which principle requires that procedures with potential pain or distress be performed with appropriate sedation, analgesia, or anesthesia?

• A. Principle 4
• B. Principle 5
• C. Principle 7
• D. Principle 9

Answer: (B)

The main idea being tested is that any procedure with potential pain or distress must be performed with appropriate analgesia, anesthesia, or sedation to minimize suffering. This principle explicitly sets the obligation to relieve pain during procedures, which is why it is the best answer here. It aligns with the overarching goal of humane care in research involving animals, requiring investigators to plan for and provide pain relief, consult veterinary staff, and obtain appropriate oversight. While other principles address related welfare considerations, they do not state this specific requirement as clearly.

The main idea being tested is that any procedure with potential pain or distress must be performed with appropriate analgesia, anesthesia, or sedation to minimize suffering. This principle explicitly sets the obligation to relieve pain during procedures, which is why it is the best answer here. It aligns with the overarching goal of humane care in research involving animals, requiring investigators to plan for and provide pain relief, consult veterinary staff, and obtain appropriate oversight. While other principles address related welfare considerations, they do not state this specific requirement as clearly.