GLP - Test System is defined as which of the following?

GLP - Test System is defined as which of the following?

• A. A computer model used for simulations
• B. An in vitro test system
• C. An animal, plant, microorganisms, or subparts receiving administration of test or control article
• D. A computer program for data analysis

Answer: (C)

GLP defines a test system as the biological substrate used to generate data in a study. That means the living thing or its part that actually receives the test article or control article—such as an animal, a plant, a microorganism, or a subpart of one of these. This focuses on the system that directly interacts with the test article. Computer models, data-analysis software, or nonliving in vitro setups are tools or methods, not the test system itself. While in vitro systems can be used under GLP, the definition that covers animals, plants, microorganisms, or their parts receiving administration best matches the formal definition, making it the correct choice.

GLP defines a test system as the biological substrate used to generate data in a study. That means the living thing or its part that actually receives the test article or control article—such as an animal, a plant, a microorganism, or a subpart of one of these. This focuses on the system that directly interacts with the test article. Computer models, data-analysis software, or nonliving in vitro setups are tools or methods, not the test system itself. While in vitro systems can be used under GLP, the definition that covers animals, plants, microorganisms, or their parts receiving administration best matches the formal definition, making it the correct choice.